| Expression pattern: |
UP |
| Associated gene: |
E2F3, Ago2 |
| Associated microRNA: |
miR-140-5p |
| Biological function: |
promotes paclitaxel resistance, cell viability, colony formation, invasion and glycolysis; enhances PTX sensitivity when knocked down (in vitro and in vivo) |
| Molecular mechanism: |
acts as a miRNA sponge for miR-140-5p to upregulate E2F3 expression |
| Biological pathway or process: |
glycolysis (promotes); invasion (promotes); proliferation (promotes); ceRNA regulation (promotes); drug resistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model |
| Clinical significance: |
Circ‐RNF111 was upregulated in PTX‐resistant BC tissues (vs PTX‐sensitive). |
| Description: |
circ-RNF111 is upregulated in paclitaxel-resistant breast cancer tissues/cells and promotes PTX resistance, proliferation-related behaviors (viability/colony formation), invasion, and glycolysis. Mechanistically, it sponges miR-140-5p to increase E2F3 expression, enhancing PTX resistance in vitro and in a nude-mouse xenograft model. |
| Confidence score: |
0.6825 |