| Expression pattern: |
UP |
| Associated gene: |
CDC25A |
| Associated microRNA: |
miR-122-5p |
| Biological function: |
Promotes CRC progression by enhancing proliferation, colony formation, migration, invasion, and tumor growth; circ_0007142 knockdown suppresses these phenotypes. |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-122-5p to increase CDC25A expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High circ_0007142 expression was significantly associated with tumor size, lymphatic metastasis, distal metastasis and advanced TNM stage, suggesting potential prognostic relevance. |
| Description: |
circ_0007142 is up-regulated in colorectal cancer and promotes malignant phenotypes (proliferation, colony formation, migration/invasion) and xenograft growth. Mechanistically, it functions as a ceRNA sponging miR-122-5p to increase CDC25A expression. |
| Confidence score: |
0.6278 |