| Expression pattern: |
UP |
| Associated gene: |
FGF2, Ago2, PI3K, Akt |
| Associated microRNA: |
miR-195-5p |
| Biological function: |
Promotes osteosarcoma progression and metastasis; promotes proliferation; inhibits apoptosis; enhances migration and invasion. |
| Molecular mechanism: |
Acts as a ceRNA by sponging miR-195-5p, thereby upregulating FGF2 and activating PI3K/Akt signaling. |
| Biological pathway or process: |
PI3K/AKT (promotes); proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); TUNEL; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Higher circ_001422 expression correlated with more advanced clinical stage, larger tumor size, higher incidence of distant metastases and poorer overall survival in OS patients; AUC of ROC was 0.752 suggesting diagnostic potential. |
| Description: |
circ_001422 is up-regulated in osteosarcoma tissues and cell lines and promotes proliferation, migration/invasion, and metastasis while inhibiting apoptosis. It functions mainly in the cytoplasm as a ceRNA that sponges miR-195-5p, thereby upregulating FGF2 and activating PI3K/Akt signaling, and its high expression is associated with poor overall survival and diagnostic value. |
| Confidence score: |
0.8981 |