| Expression pattern: |
UP |
| Associated gene: |
NCOA3 |
| Associated microRNA: |
miR-4458 |
| Biological function: |
Circ_0001667 promotes ADM-resistant breast cancer cell proliferation, migration, invasion, tumor growth and ADM resistance, and inhibits ADM-induced apoptosis; circ_0001667 knockdown suppresses these malignant behaviors and attenuates ADM resistance. |
| Molecular mechanism: |
Circ_0001667 acts as a ceRNA/miRNA sponge for miR-4458, thereby relieving miR-4458-mediated repression of NCOA3 and promoting ADM resistance and malignant progression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); drug resistance (promotes); chemoresistance (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Western Blot; Annexin V/PI Flow Cytometry; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
- |
| Description: |
Circ_0001667 is up-regulated in ADM-resistant breast cancer tissues and cells. Its knockdown suppresses proliferation, migration, invasion, tumor growth and ADM resistance while promoting ADM-induced apoptosis. Mechanistically, circ_0001667 functions through the circ_0001667/miR-4458/NCOA3 axis, acting as a miR-4458 sponge to maintain NCOA3 expression and promote chemoresistant malignant progression. |
| Confidence score: |
0.8324 |