| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa-mir-3677, hsa-mir-188 |
| Biological function: |
Potential tumor-suppressive role; associated with HCC proliferation and progression; may inhibit proliferation. |
| Molecular mechanism: |
Predicted circRNA-miRNA-mRNA network (ceRNA-like prediction) using TCGA-LIHC RNA-seq/miRNA-seq and miRNA target prediction tools. |
| Biological pathway or process: |
proliferation (inhibits); inflammation (other); stemness (other); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Cohort Study; Bioinformatics Analysis |
| Clinical significance: |
High hsa_circ_0005986 expression was associated with improved overall and progression-free survival and was an independent prognostic factor; low expression associated with larger tumors, advanced TNM stage, and higher BCLC stage. |
| Description: |
hsa_circ_0005986 is down-regulated in HCC tissues and lower in more advanced TNM/BCLC stages. Higher expression predicts better overall and progression-free survival, supporting its role as an independent prognostic biomarker. Bioinformatic analyses further predicted a circRNA-miRNA-mRNA network (including hsa-mir-3677 and hsa-mir-188), suggesting potential involvement in proliferation/inflammation-related processes. |
| Confidence score: |
0.6201 |