| Expression pattern: |
UP |
| Associated gene: |
MDM2 |
| Associated microRNA: |
miR-498 |
| Biological function: |
promotes proliferation, migration, invasion, and tumor growth; promotes metastasis/EMT-like changes (decreases E-cadherin and increases N-cadherin, Vimentin, Snail) |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-498 to regulate MDM2 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Bioinformatics Analysis; RT-qPCR; RNase R Treatment; divergent primers PCR; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Clinical Sample Validation; RNA-seq |
| Clinical significance: |
High expression of circMCTP2 predicted a poor prognosis of BC patients. |
| Description: |
CircMCTP2 is up-regulated in bladder carcinoma and promotes proliferation, migration/invasion, and tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-498 to increase MDM2, and high circMCTP2 expression is associated with poor overall survival. |
| Confidence score: |
0.8568 |