circRNA basic information
circBase ID: hsa_circ_0004771
Name: hsa_circ_NRIP
Synonym: -
Host Gene: NRIP
Genomic location(hg19): chr21:16386664-16415895:-
Genomic location(hg38): chr21:15014343-15043574:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

GES-1; SGC-7901; AGS; MKN-45; MGC-803; HGC-27; BGC-823
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HIF-1alpha, MDR1, P-glycoprotein
Associated microRNA: miR-138-5p
Biological function: Maintains hypoxia-induced resistance to 5-fluorouracil and promotes glycolytic glucose metabolism in gastric cancer cells.
Molecular mechanism: Acts as a miR-138-5p sponge to upregulate HIF-1alpha, thereby enhancing HIF-1alpha-dependent glycolysis and hypoxia-induced 5-FU resistance.
Biological pathway or process:

glycolysis (promotes); chemoresistance (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Western Blot; Luciferase Reporter Assay; Transfection; MTT; Bioinformatics Analysis
Clinical significance:

-
Description:

circNRIP1 is upregulated in gastric cancer cell lines, further induced by hypoxia, and promotes hypoxia-associated 5-FU chemoresistance. Mechanistically, it sponges miR-138-5p to relieve repression of HIF-1alpha, enhancing HIF-1alpha-dependent glycolysis (increased glucose consumption, lactate and G6P), thereby sustaining drug resistance.
Confidence score:

0.5416
Other information
Title:

Circular RNA circNRIP1 Sponges microRNA-138-5p to Maintain Hypoxia-Induced Resistance to 5-Fluorouracil Through HIF-1alpha-Dependent Glucose Metabolism in Gastric Carcinoma.

Journal: Cancer management and research
Published: 2020
PubMed ID: 32425596
Study type:

biological research
Data availability: -
Code availability: -