circRNA basic information
circBase ID: hsa_circ_0001658
Name: hsa_circ_RAB10
Synonym: circ_0001658
Host Gene: RAB10
Genomic location(hg19): chr6:157357968-157406039:+
Genomic location(hg38): chr6:157036834-157084905:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues
Cell lines:

AGS; HGC27; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RAB10
Associated microRNA: miR-182
Biological function: Promotes GC cell viability and autophagy; inhibits apoptosis (knockdown inhibits viability and autophagy and promotes apoptosis).
Molecular mechanism: ceRNA (miRNA sponge): circ_0001658 sponges miR-182 to suppress miR-182 and thereby increase RAB10 expression.
Biological pathway or process:

autophagy (promotes); apoptosis (inhibits); proliferation (promotes); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; IF (Immunofluorescence)
Clinical significance:

-
Description:

hsa_circ_0001658 is up-regulated in gastric cancer and promotes GC cell viability and autophagy while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-182 to relieve repression of RAB10, forming the circ_0001658/miR-182/RAB10 axis.
Confidence score:

0.657
Other information
Title:

Circular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis.

Journal: Bioengineered
Published: 2022
PubMed ID: 35030981
Study type:

biological research
Data availability: GSE93541; GSE89143; GSE78092
Code availability: -