| Expression pattern: |
DN |
| Associated gene: |
FOXK2 |
| Associated microRNA: |
miR-148a-3p |
| Biological function: |
inhibits proliferation, migration, and invasion; promotes apoptosis; induces G1 phase arrest |
| Molecular mechanism: |
circUBAP2 acts as a miRNA sponge for miR-148a-3p, thereby regulating FOXK2 |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); cell cycle (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
circUBAP2 might serve as a potential therapeutic target for the treatment of ccRCC |
| Description: |
circUBAP2 is down-regulated in ccRCC tissues and cell lines. circUBAP2 suppresses ccRCC cell proliferation, migration and invasion, promotes apoptosis and G1 arrest, by sponging miR-148a-3p to regulate the downstream target FOXK2. |
| Confidence score: |
0.6536 |