| Expression pattern: |
UP |
| Associated gene: |
ZEB2 |
| Associated microRNA: |
miR-593-3p |
| Biological function: |
Promotes osteosarcoma cell proliferation, migration and invasion, inhibits cell death/apoptosis, and promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/molecular sponge for miR-593-3p to facilitate ZEB2 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Survival Analysis; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Upregulated in OS and correlated with advanced stage; overexpression predicted poor prognosis and low survival rate in OS patients. |
| Description: |
hsa_circ_0136666 is upregulated in osteosarcoma and associated with advanced stage and poor prognosis. It promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis by sponging miR-593-3p to increase ZEB2 expression. |
| Confidence score: |
0.7369 |