| Expression pattern: |
UP |
| Associated gene: |
Bcl-2 |
| Associated microRNA: |
miR-143 |
| Biological function: |
Promotes osteosarcoma growth/proliferation and inhibits apoptosis; associated with progression and poor prognosis. |
| Molecular mechanism: |
Acts as a miR-143 sponge to suppress miR-143, thereby upregulating anti-apoptotic Bcl-2 and inhibiting apoptosis. |
| Biological pathway or process: |
apoptosis (inhibits); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model |
| Clinical significance: |
Increased circUBAP2 expression correlates with tumor stage and reduced survival/poor prognosis; may be useful for prognosis prediction and pathological identification. |
| Description: |
circUBAP2 is up-regulated in osteosarcoma tissues and cell lines and correlates with advanced stage and worse overall survival. Functionally, it promotes tumor growth by inhibiting apoptosis via sponging miR-143 and thereby increasing Bcl-2 expression, with in vitro and xenograft evidence. |
| Confidence score: |
0.7816 |