circRNA basic information
circBase ID: -
Name: hsa_circ_SKA3
Synonym: circSKA3
Host Gene: SKA3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

GBM tissue; adjacent non-cancer tissue
Cell lines:

U87
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: miR-1 gene
Associated microRNA: miR-1
Biological function: promotes GBM cell proliferation
Molecular mechanism: circSKA3 downregulates miR-1 by increasing methylation of the miR-1 gene
Biological pathway or process:

proliferation (promotes); m6A modification (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; MSP (Methylation-Specific PCR); CCK8; Cohort Study; Survival Analysis
Clinical significance:

High expression levels of circSKA3 were significantly correlated with the poor survival of GBM patients.
Description:

circSKA3 is up-regulated in glioblastoma and acts as an oncogenic circRNA by promoting GBM cell proliferation. Mechanistically, circSKA3 overexpression increases methylation of the miR-1 gene, leading to reduced miR-1 expression, and high circSKA3 expression is associated with poorer overall survival in GBM patients.
Confidence score:

0.6866
Other information
Title:

CircSKA3 Downregulates miR-1 Through Methylation in Glioblastoma to Promote Cancer Cell Proliferation.

Journal: Cancer management and research
Published: 2021
PubMed ID: 33500664
Study type:

combined biological and clinical study
Data availability: -
Code availability: -