| Expression pattern: |
UP |
| Associated gene: |
TRIP13 |
| Associated microRNA: |
miR-615-5p |
| Biological function: |
Suppresses radiosensitivity; promotes proliferation and metastasis; inhibits apoptosis; promotes tumor growth |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-615-5p to regulate TRIP13 expression, affecting radiosensitivity |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Colony Formation Assay; CCK8; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
High circ_0062020 expression is associated with larger tumor size, higher malignancy and worse prognosis; associated with Gleason score, Tumor size, TNM stages and Lymphatic metastasis |
| Description: |
circ_0062020 is up-regulated in prostate cancer (especially radioresistant tumors) and reduces radiosensitivity. Mechanistically, it functions as a ceRNA by sponging miR-615-5p to upregulate TRIP13, thereby promoting proliferation/metastasis and inhibiting apoptosis under ionizing radiation, and it supports tumor growth in vivo. |
| Confidence score: |
0.6544 |