| Expression pattern: |
UP |
| Associated gene: |
RBBP5, Vimentin |
| Associated microRNA: |
- |
| Biological function: |
circ_001659 promotes CRC cell invasion, migration and metastasis, and serves as a diagnostic and prognostic serum biomarker for CRC. |
| Molecular mechanism: |
circ_001659 is mainly nuclear and recruits RBBP5 to the Vimentin promoter, increasing H3K4 trimethylation and epigenetically activating Vimentin transcription to promote invasion and metastasis. |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); TGF-beta/SMAD (other); other pathway/process (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; RNA-seq; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; ChIP / ChIP-seq; Luciferase Reporter Assay; Transfection; Transwell Assay; In Vivo Animal Model; Western Blot; Cohort Study; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circ_001659 may serve as a reliable biomarker complementary for CEA in CRC early diagnosis and therapeutic monitoring; elevated serum circ_001659 after therapy predicts poor prognosis for CRC patients. |
| Description: |
circ_001659 is up-regulated in serum from CRC patients and shows diagnostic value, including for early-stage and CEA-negative CRC. Functionally, it promotes CRC cell migration, invasion and metastasis. Mechanistically, nuclear circ_001659 interacts with RBBP5 and recruits it to the Vimentin promoter, increasing H3K4 trimethylation and activating Vimentin transcription. |
| Confidence score: |
0.8913 |