| Expression pattern: |
UP |
| Associated gene: |
CDX2, PCNA, Bax, E-cadherin, MRP1 |
| Associated microRNA: |
miR-637 |
| Biological function: |
Facilitates cisplatin resistance and gastric cancer progression; promotes cell viability, proliferation, migration and invasion; inhibits cell cycle arrest and apoptosis; knockdown enhances CDDP sensitivity and suppresses tumour growth in vivo. |
| Molecular mechanism: |
circ_0017274 functions as a miR-637 sponge and regulates the miR-637/CDX2 axis to promote CDDP resistance in gastric cancer. |
| Biological pathway or process: |
ceRNA regulation (promotes); drug resistance (promotes); chemoresistance (promotes); proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
circ_0017274 could be involved in CDDP resistance in GC and could potentially be a molecular marker for GC diagnosis and a target for improving drug resistance. |
| Description: |
circ_0017274 is up-regulated in cisplatin-resistant gastric cancer tissues and cells. It promotes CDDP resistance and malignant phenotypes by sponging miR-637 and regulating CDX2, while circ_0017274 knockdown enhances CDDP sensitivity, suppresses proliferation, migration and invasion, promotes apoptosis, and inhibits xenograft tumour growth. |
| Confidence score: |
0.8325 |