| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
May promote tumor metastasis and tumor progression; potential non-invasive diagnostic and prognostic biomarker |
| Molecular mechanism: |
Not specified; molecular mechanisms in metastasis not determined |
| Biological pathway or process: |
metastasis (other); invasion (other); migration (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Survival Analysis |
| Clinical significance: |
Plasma hsa_circ_0001715 had diagnostic value (AUC 0.871) and high plasma levels were associated with shorter OS and were an independent prognostic factor for OS. |
| Description: |
hsa_circ_0001715 is up-regulated in lung adenocarcinoma tissues and elevated in patient plasma. Its plasma level correlates with TNM stage and distant metastasis, shows strong diagnostic performance (AUC 0.871), and high plasma expression predicts poorer overall survival as an independent prognostic factor. |
| Confidence score: |
0.6939 |