| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-147b, hsa-miR-19b-1-5p, hsa-miR-134-3p, hsa-miR-576-5p, hsa-miR-493-5p |
| Biological function: |
May have a proinflammatory role in IBD; associated with higher disease activity and complicated CD behavior (stricturing/penetrating). |
| Molecular mechanism: |
Predicted miRNA sponging, with a reported negative correlation with hsa-miR-19b-1-5p (no experimental binding validation). |
| Biological pathway or process: |
inflammation (promotes); immune regulation (other); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Candidate diagnostic biomarker for IBD (AUC 0.790 for CD; 0.687 for UC) and associated with disease activity/behavior. |
| Description: |
circRNA_103516 is up-regulated in PBMCs from adult IBD patients (CD and UC) and shows diagnostic value by ROC analysis. Higher circRNA_103516 levels are associated with active disease and correlate with inflammatory cytokines, suggesting a proinflammatory role. Mechanistically, it is proposed to function as a miRNA sponge (not experimentally validated), with a negative correlation observed with hsa-miR-19b-1-5p in CD. |
| Confidence score: |
0.5121 |