| Expression pattern: |
UP |
| Associated gene: |
SOX9, Met |
| Associated microRNA: |
miR-487a-3p, miR-338-3p |
| Biological function: |
promotes proliferation; promotes migration; promotes invasion; promotes cisplatin resistance; inhibits apoptosis |
| Molecular mechanism: |
circ_0020095 acts as a miRNA sponge for miR-487a-3p to relieve repression of SOX9 (3′-UTR), promoting oncogenic phenotypes and cisplatin resistance; additionally regulates Met via miR-338-3p. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
B
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Northern Blot; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
circ_0020095 expression was higher in metastatic CC tissues than in non-metastatic tissues |
| Description: |
circ_0020095 (hsa_circ_0020095), derived from ATRNL1, is up-regulated in colon cancer tissues/cell lines and promotes proliferation, migration, invasion and cisplatin resistance while inhibiting apoptosis. It mainly functions as a cytoplasmic ceRNA that sponges miR-487a-3p to increase SOX9 (and also regulates Met via miR-338-3p), and its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.8533 |