| Expression pattern: |
UP |
| Associated gene: |
RET, PI3K/Akt signaling pathway |
| Associated microRNA: |
miR-636 |
| Biological function: |
promotes proliferation and migration/invasion and inhibits apoptosis in NSCLC cells |
| Molecular mechanism: |
Acts as a sponge for miR-636 to regulate RET, affecting PI3K/Akt signaling (and p-ERK). |
| Biological pathway or process: |
PI3K/AKT (promotes); ERK (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; IF (Immunofluorescence); Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In NSCLC cell lines, circRNA_100876 promotes malignant phenotypes (proliferation, migration/invasion) and suppresses apoptosis. Mechanistically it sponges miR-636 to de-repress RET and activate PI3K/Akt signaling (with reduced p-Akt and p-ERK upon knockdown). |
| Confidence score: |
0.5627 |