| Expression pattern: |
DN |
| Associated gene: |
PIK3R1, VEGF-C, Akt, GSK3beta |
| Associated microRNA: |
miR-486-5p |
| Biological function: |
inhibits lymphangiogenesis and lymph node metastasis; inhibits migration; suppresses tumorigenesis |
| Molecular mechanism: |
acts as a ceRNA/miRNA sponge for miR-486-5p, relieving repression of PIK3R1, inhibiting PI3K/Akt signaling and reducing VEGF-C expression/secretion |
| Biological pathway or process: |
PI3K/AKT (inhibits); lymphangiogenesis (inhibits); metastasis (inhibits); migration (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Sanger Sequencing; divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; Luciferase Reporter Assay; Transfection; Transwell Assay; Tube Formation Assay; Western Blot; ELISA; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis; Clinical Sample Validation; Cohort Study |
| Clinical significance: |
Low circNFIB1 expression is associated with LN metastasis and poor overall survival and disease-free survival; circNFIB1 is an independent prognostic factor for good prognosis |
| Description: |
circNFIB1 (hsa_circ_0086375), derived from NFIB, is down-regulated in PDAC and inversely associated with lymph node metastasis. It mainly localizes to the cytoplasm and acts as a miR-486-5p sponge to upregulate PIK3R1, inhibit PI3K/AKT signaling, reduce VEGF-C, and thereby suppress lymphangiogenesis and lymphatic metastasis; low circNFIB1 predicts worse patient survival. |
| Confidence score: |
0.8886 |