| Expression pattern: |
UP |
| Associated gene: |
TPD52 |
| Associated microRNA: |
miR-1182 |
| Biological function: |
promotes docetaxel resistance, proliferation, migration and invasion, and inhibits apoptosis and G0/G1 cell cycle arrest in DTX-resistant PCa cells; promotes tumor growth and reduces DTX sensitivity in vivo |
| Molecular mechanism: |
Exosomal circ-XIAP acts as a miRNA sponge for miR-1182, thereby upregulating TPD52 and promoting docetaxel resistance (ceRNA mechanism). |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Western Blot; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ-XIAP is upregulated in docetaxel-resistant prostate cancer tissues/cells and enriched in exosomes. It promotes DTX resistance by acting as a sponge for miR-1182, thereby increasing TPD52 expression, enhancing malignant phenotypes and reducing chemosensitivity in vitro and in a xenograft model. |
| Confidence score: |
0.7421 |