circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circ_001569
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary osteosarcoma tissues; adjacent non-cancerous bone tissues
Cell lines:

U2OS; MG-63; hFOB
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: p-GSK-3beta, GSK-3beta, beta-catenin
Associated microRNA: -
Biological function: promotes osteosarcoma cell proliferation and colony formation; promotes chemotherapy resistance (cisplatin resistance)
Molecular mechanism: activates the Wnt/beta-catenin signaling pathway, accompanied by increased p-GSK-3beta and beta-catenin and decreased GSK-3beta
Biological pathway or process:

Wnt/beta-catenin (promotes); proliferation (promotes); chemoresistance (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Western Blot
Clinical significance:

Higher circ_001569 expression significantly correlated with distant metastasis and advanced tumor stage of osteosarcoma patients; correlated with poor prognosis
Description:

circ_001569 is up-regulated in osteosarcoma tissues and cell lines and is associated with distant metastasis and advanced TNM stage. Functionally, circ_001569 promotes osteosarcoma cell proliferation/colony formation and increases cisplatin (and other chemotherapy) resistance by activating the Wnt/beta-catenin signaling pathway.
Confidence score:

0.5358
Other information
Title:

Expression of circ_001569 is upregulated in osteosarcoma and promotes cell proliferation and cisplatin resistance by activating the Wnt/beta-catenin signaling pathway.

Journal: Oncology letters
Published: 2018
PubMed ID: 30344736
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -