circRNA basic information
circBase ID: hsa_circ_0006417
Name: hsa_circ_NEAT1
Synonym: -
Host Gene: NEAT1
Genomic location(hg19): chr11:65202523-65205128:+
Genomic location(hg38): chr11:65435052-65437657:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

Fresh tissues of PTC; adjacent normal thyroid; paraffin-embedded tissue slides
Cell lines:

TPC-1; BCPAP; K1; IHH-4; Nthy-ori3-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SYK, mTOR, 4E-BP1
Associated microRNA: miR-377-3p
Biological function: hsa_circ_0006417 facilitates PTC progression and promotes PTC cell proliferation, migration, and invasion through the miR-377-3p/SYK axis and activation of the mTOR/4E-BP1 signaling pathway.
Molecular mechanism: ceRNA mechanism: hsa_circ_0006417 sponges miR-377-3p to regulate SYK expression and activate the mTOR/4E-BP1 signaling pathway.
Biological pathway or process:

ceRNA regulation (promotes); PI3K/AKT/mTOR (promotes); proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
S
Validation methods:

Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0006417 is upregulated in papillary thyroid cancer tissues and cells. It acts as a tumor-promoting ceRNA by sponging miR-377-3p, thereby increasing SYK expression and activating the mTOR/4E-BP1 signaling pathway to promote PTC cell proliferation, migration, and invasion.
Confidence score:

0.8115
Other information
Title:

Spleen tyrosine kinase facilitates the progression of papillary thyroid cancer regulated by the hsa_circ_0006417/miR-377-3p axis.

Journal: Environmental toxicology
Published: 2024
PubMed ID: 37792549
Study type:

combined biological and clinical study
Data availability: GSE171011; data available from the authors upon reasonable request
Code availability: -