circRNA basic information
circBase ID: hsa_circ_0000517
Name: hsa_circ_RPPH1
Synonym: circRPPH1
Host Gene: RPPH1
Genomic location(hg19): chr14:20811404-20811492:-
Genomic location(hg38): chr14:20343245-20343333:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; paired normal tissues
Cell lines:

SMMC-7721
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

potentially valuable diagnostic biomarkers for HCC treatment
Description:

hsa_circ_0000517 (circRPPH1) is one of six circRNAs found up-regulated in HCC and validated by RT-qPCR in SMMC-7721 cells. The paper proposes it as a potential diagnostic biomarker, without defining a specific miRNA/mRNA regulatory axis for it.
Confidence score:

0.4032
Other information
Title:

Identification and integrated analysis of hepatocellular carcinoma-related circular RNA signature.

Journal: Annals of translational medicine
Published: 2020
PubMed ID: 32355738
Study type:

combined biological and clinical study
Data availability: GSE94508; GSE97332
Code availability: -