| Expression pattern: |
DN |
| Associated gene: |
downstream target protein genes |
| Associated microRNA: |
miR-593-5p, miR-103a-3p, miR-107 |
| Biological function: |
Plays significant roles in gastric carcinogenesis and progression; associated with invasion and lymphatic metastasis. |
| Molecular mechanism: |
Predicted miRNA sponge/ceRNA mechanism via miR-593-5p, miR-103a-3p, and miR-107 to regulate downstream target genes. |
| Biological pathway or process: |
cell cycle (other); p53 signaling (other); metabolic processes (other); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Expression decreased in 78.02% (71/91) GC patients; ROC AUC 0.673 (sensitivity 61.54%, specificity 68.13%); associated with differentiation, tumor stage, invasion, lymphatic metastasis and CEA level. |
| Description: |
hsa_circ_0001874 is down-regulated in gastric cancer tissues and GC cell lines and is proposed as a diagnostic indicator (AUC 0.673). Bioinformatics predicts it acts as a miRNA sponge for miR-593-5p, miR-103a-3p and miR-107, potentially influencing cell cycle-, p53 signaling- and metabolism-related processes via downstream target genes. |
| Confidence score: |
0.5963 |