| Expression pattern: |
DN |
| Associated gene: |
KLF15 |
| Associated microRNA: |
miR-182-5p |
| Biological function: |
inhibits proliferation and invasion of ovarian cancer cells; acts as a tumor suppressor |
| Molecular mechanism: |
ceRNA mechanism: circMTO1 sponges miR-182-5p to support KLF15 expression |
| Biological pathway or process: |
proliferation (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
circMTO1 as a novel biomarker and therapeutic target for ovarian cancer treatment |
| Description: |
circMTO1 is down-regulated in ovarian cancer tissues and cell lines and functions as a tumor suppressor by inhibiting ovarian cancer cell proliferation and invasion. It acts as a ceRNA by sponging miR-182-5p, thereby supporting KLF15 expression and suppressing ovarian cancer progression. |
| Confidence score: |
0.6479 |