| Expression pattern: |
UP |
| Associated gene: |
RAB1A |
| Associated microRNA: |
miR-526b-5p |
| Biological function: |
promotes proliferation, colony formation, cell cycle progression, migration, invasion, and tumor growth in HCC |
| Molecular mechanism: |
circUGGT2 functions as a ceRNA sponge for miR-526b-5p to increase RAB1A expression |
| Biological pathway or process: |
proliferation (promotes); cell cycle (promotes); migration (promotes); invasion (promotes); metastasis (other); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Colony Formation Assay; Western Blot; Cell Cycle Assay; Transwell Assay; In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis; Microarray |
| Clinical significance: |
- |
| Description: |
circUGGT2 (hsa_circ_0008274) is up-regulated in HCC tissues and cell lines and is mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, colony formation, cell-cycle progression, migration/invasion) and tumor growth by sponging miR-526b-5p to derepress RAB1A (circUGGT2/miR-526b-5p/RAB1A ceRNA axis). |
| Confidence score: |
0.8206 |