| Expression pattern: |
UP |
| Associated gene: |
TNF-alpha, TNF, p65, MMP3, MMP13, ADAMTS4 |
| Associated microRNA: |
miR-330-3p |
| Biological function: |
promotes synoviocyte proliferation; induces chondrocyte apoptosis; promotes cartilage ECM degradation; induces inflammation; decreases anabolism of the extracellular matrix |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: circGCN1L1 sponges miR-330-3p to upregulate TNF-alpha and activate NF-kappaB-associated inflammatory/apoptotic signaling. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (promotes); NF-kappaB (promotes); inflammation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; EdU Staining; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; ELISA; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
may have clinical significance for TMJOA |
| Description: |
circGCN1L1 is up-regulated in TMJOA synovial tissues/cells and predominantly localizes in the cytoplasm. It functions as a ceRNA/miRNA sponge for miR-330-3p, thereby relieving repression on TNF (TNF-alpha) and promoting inflammatory responses, synoviocyte proliferation, chondrocyte apoptosis, and ECM catabolism; shcircGCN1L1 injection alleviates TMJOA in rats. |
| Confidence score: |
0.8072 |