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HCC827/GR; PC9/GR; HCC827; PC9
ceRNA regulation (other); drug resistance (other)
RNA-seq; RNase R Treatment; RT-qPCR; Bioinformatics Analysis
Several target mRNAs of hsa_circ_0006867 had been shown to significantly associate with the overall survival of patients with lung cancer
hsa_circ_0006867 (host gene LRBA) is consistently down-regulated in gefitinib-resistant NSCLC cell lines. The study predicts it may function as a miRNA sponge (e.g., binding hsa-miR-204-3p, hsa-miR-671- 5p, hsa-miR-145-5p, hsa-miR-1237-3p, hsa-miR- 1182) and influence downstream mRNAs implicated in gefitinib resistance and lung cancer overall survival (based on target mRNA analyses).
0.3858
Screening Circular RNAs Related to Acquired Gefitinib Resistance in Non-small Cell Lung Cancer Cell Lines.
biological research