circRNA basic information
circBase ID: hsa_circ_0000567
Name: hsa_circ_SETD3
Synonym: -
Host Gene: SETD3
Genomic location(hg19): chr14:99924615-99932150:-
Genomic location(hg38): chr14:99458278-99465813:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

HCC827/GR; PC9/GR; HCC827; PC9
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MET, AKT1, ABCB1, IGF1R
Associated microRNA: hsa-miR-1226-5p, hsa-miR-762, hsa-miR-593-5p, hsa-miR-149-5p, hsa-miR-939-3p
Biological function: might regulate gefitinib sensitivity and contribute to acquired resistance to gefitinib in NSCLC
Molecular mechanism: predicted to act as a miRNA sponge and participate in circRNA-miRNA-mRNA networks
Biological pathway or process:

ceRNA regulation (other); drug resistance (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; RT-qPCR; Bioinformatics Analysis
Clinical significance:

Several target mRNAs of hsa_circ_0000567 had been shown to significantly associate with the overall survival of patients with lung cancer
Description:

hsa_circ_0000567 (host gene SETD3) is consistently up-regulated in gefitinib-resistant NSCLC cell lines and is proposed to modulate gefitinib sensitivity. The study predicts it may function as a miRNA sponge (e.g., binding hsa-miR-1226-5p, hsa-miR-762, hsa-miR-593-5p, hsa-miR-149-5p, hsa-miR-939-3p) to influence downstream mRNAs implicated in resistance (e.g., MET, AKT1, ABCB1, IGF1R).
Confidence score:

0.3858
Other information
Title:

Screening Circular RNAs Related to Acquired Gefitinib Resistance in Non-small Cell Lung Cancer Cell Lines.

Journal: Journal of Cancer
Published: 2020
PubMed ID: 32328186
Study type:

biological research
Data availability: -
Code availability: -