circRNA basic information
circBase ID: hsa_circ_0066629
Name: hsa_circ_DCBLD2
Synonym: -
Host Gene: DCBLD2
Genomic location(hg19): chr3:98541071-98541585:-
Genomic location(hg38): chr3:98822227-98822741:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

exosomes
Cell lines:

HCT116
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: Bioinformatics-predicted circRNA-miRNA-mRNA associations (MRE-based).
Biological pathway or process:

ceRNA regulation (other); drug resistance (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0066629 is upregulated in exosomes from FOLFOX-resistant HCT116-R CRC cells compared with parental cells and was selected as a validated candidate circRNA from the microarray screen. Its downstream mechanism was only explored via in-silico circRNA-miRNA-mRNA prediction without specific validated targets reported.
Confidence score:

0.4761
Other information
Title:

Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer.

Journal: Scientific reports
Published: 2019
PubMed ID: 31712601
Study type:

combined biological and clinical study
Data availability: Supplementary information is available for this paper at 10.1038/s41598-019-53063-y.
Code availability: -