| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-136, miR-622, hsa-miR-622, hsa-miR-136-5p |
| Biological function: |
May be involved in the occurrence and development of APTB; proposed as a diagnostic biomarker for APTB. |
| Molecular mechanism: |
Bioinformatically predicted miRNA binding (miR-622, miR-136-5p) and predicted m6A modification sites; mechanistic function not experimentally validated. |
| Biological pathway or process: |
ceRNA regulation (other); m6A modification (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; circRNA-seq; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Downregulated in PBMCs of APTB patients and shows high diagnostic value (AUC=0.9502; sensitivity 93.75%; specificity 87.50%). |
| Description: |
hsa_circ_0001380 (derived from UBXN7) is significantly downregulated in PBMCs/peripheral blood of active pulmonary tuberculosis patients and shows strong diagnostic performance by ROC analysis (AUC 0.9502). Its miRNA binding (miR-622/miR-136-5p) and m6A sites were predicted in silico, but downstream targets and mechanisms were not experimentally validated. |
| Confidence score: |
0.6548 |