circRNA basic information
circBase ID: hsa_circ_0001947
Name: hsa_circ_AFF2
Synonym: -
Host Gene: AFF2
Genomic location(hg19): chrX:147743428-147744289:+
Genomic location(hg38): chrX:148661907-148662768:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008383
MONDO name: rheumatoid arthritis
Disease details: new-onset rheumatoid arthritis
Disease DO ID:
 7148
Disease MeSH ID:
 D001172
Disease NCIt ID:
 C2884
Disease ICD11 ID:
 576319925
Disease OMIM ID:
 180300
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: AFF2
Associated microRNA: Hsa-mir-10b-3p, Hsa-mir-26b-3p, Hsa-mir-92a-2-5p, Hsa-mir-488-3p, Hsa-mir-329-5p
Biological function: Potential diagnostic biomarker; associated with ACPA positivity and hematologic indices in RA
Molecular mechanism: miRNA target prediction suggests potential sponge mechanism (not experimentally validated)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Peripheral blood hsa_circ_0001947 can distinguish new-onset RA patients from HC, AS patients, SLE patients, and UA patients (ROC analysis).
Description:

hsa_circ_0001947 is up-regulated in peripheral blood of new-onset RA patients and can differentiate RA from controls and comparator disease groups including UA. It is linked to ACPA positivity and other hematological parameters, and predicted miRNA targets indicate a potential miRNA-sponge role.
Confidence score:

0.459
Other information
Title:

Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in Peripheral Blood Are Novel Potential Biomarkers for New-Onset Rheumatoid Arthritis.

Journal: Disease markers
Published: 2019
PubMed ID: 31772684
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding authors upon request.
Code availability: -