| Expression pattern: |
UP |
| Associated gene: |
ASIC1 |
| Associated microRNA: |
miR-103a-3p |
| Biological function: |
promotes Ishikawa cell migration, invasion, proliferation, and epithelial-mesenchymal transition in endometriosis |
| Molecular mechanism: |
circATRNL1 binds miR-103a-3p and upregulates ASIC1, thereby promoting EMT and cell invasion in endometriosis |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Wound Healing Assay; Transwell Assay; CCK8; Colony Formation Assay; Western Blot |
| Clinical significance: |
circATRNL1 might be a novel therapeutic candidate target for endometriosis treatment |
| Description: |
circATRNL1 is upregulated in endometriosis-related endometrial cancer cell lines and promotes Ishikawa cell proliferation, migration, invasion, and EMT. Mechanistically, circATRNL1 binds miR-103a-3p and increases ASIC1 expression, forming a circATRNL1/miR-103a-3p/ASIC1 axis that may serve as a therapeutic target for endometriosis. |
| Confidence score: |
0.5627 |