circRNA basic information
circBase ID: -
Name: hsa_circ_ZKSCAN1
Synonym: circZKSCAN1 / circZKSCAN
Host Gene: ZKSCAN1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005148
MONDO name: type 2 diabetes mellitus
Disease details: type 2 diabetes
Disease DO ID:
 9352
Disease MeSH ID:
 D003924
Disease NCIt ID:
 C26747
Disease ICD11 ID:
 119724091
Disease OMIM ID:
 125853
Species: Human
Species details: Homo sapiens
Tissue specimen:

human pancreatic islets; peripheral blood
Cell lines:

EndoC-betaH1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with T2D status in islets; discussed as potentially inhibiting proliferation and survival.
Molecular mechanism: Correlative; no direct mechanism tested.
Biological pathway or process:

proliferation (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation
Clinical significance:

Associated with T2D status in islets (nominal); detected in peripheral blood but not associated with T2D status in blood in this study.
Description:

circZKSCAN1 shows a nominal association with T2D status in human islets and is discussed in the context of inhibiting cellular proliferation/survival. It is detectable in peripheral blood in this study, but the reported blood association with T2D status is for circCAMSAP1 rather than circZKSCAN1.
Confidence score:

0.2995
Other information
Title:

Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood.

Journal: BMC medical genomics
Published: 2020
PubMed ID: 32312268
Study type:

combined biological and clinical study
Data availability: PRJNA607015; SRR11095576; SRR11095575
Code availability: -