circRNA basic information
circBase ID: -
Name: hsa_circ_EZH2
Synonym: novel_circ_004401 / circCIMT
Host Gene: EZH2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008903
MONDO name: lung cancer
Disease details: lung cancer
Disease DO ID:
 1324
Disease MeSH ID:
 -
Disease NCIt ID:
 C7377
Disease ICD11 ID:
 -
Disease OMIM ID:
 211980
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung cancer tissue; normal lung tissues; para‐carcinoma tissues; mouse lung tissue; blood; urine; mouse plasma
Cell lines:

BEAS‐2B; 16HBE
In vivo animal model:

cell line-derived xenograft; other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: APEX1, XRCC1, PARP1, LIG3
Associated microRNA: -
Biological function: Suppresses Cd-induced malignant transformation, migration and invasion; suppresses Cd-induced DNA damage
Molecular mechanism: circCIMT binds APEX1 and regulates nuclear BER complex protein expression during Cd exposure, reducing DNA damage
Biological pathway or process:

other pathway/process (inhibits); migration (inhibits); invasion (inhibits); proliferation (inhibits)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; Western Blot; IF (Immunofluorescence); Transwell Assay; CCK8; EdU Staining; Colony Formation Assay; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis
Clinical significance:

Decreased circCIMT expression was found in lung cancer tissue
Description:

circCIMT (novel_circ_004401), derived from EZH2, is down-regulated after cadmium exposure and in lung cancer tissues. It binds APEX1 and supports the BER DNA repair program; circCIMT knockdown increases DNA damage and promotes Cd-induced malignant transformation, migration, and invasion of lung epithelial cells.
Confidence score:

0.7224
Other information
Title:

circCIMT Silencing Promotes Cadmium-Induced Malignant Transformation of Lung Epithelial Cells Through the DNA Base Excision Repair Pathway.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published: 2023
PubMed ID: 36814305
Study type:

combined biological and clinical study
Data availability: SRA: SRP415355
Code availability: -