circRNA basic information
circBase ID: hsa_circ_0014235
Name: hsa_circ_S100A2
Synonym: -
Host Gene: S100A2
Genomic location(hg19): chr1:153536209-153536363:-
Genomic location(hg38): chr1:153563733-153563887:-
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005097
MONDO name: squamous cell lung carcinoma
Disease details: lung squamous cell carcinoma
Disease DO ID:
 3907
Disease MeSH ID:
 -
Disease NCIt ID:
 C3493
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosome
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential diagnostic biomarker for LUSC; associated with higher TNM stage and larger tumor size.
Molecular mechanism: circRNAs-miRNAs-mRNAs interaction network (predicted); may be involved in cancer-related pathways.
Biological pathway or process:

cell cycle (other); JAK/STAT (other); Wnt/beta-catenin (other)
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Increased expression correlates with higher TNM stage and larger tumor size; ROC analysis shows acceptable diagnostic value (AUC = 0.8254).
Description:

hsa_circ_0014235 is up-regulated in plasma exosomes from LUSC patients and shows diagnostic potential (AUC ~0.83). It is associated with more advanced clinical features (higher TNM stage and larger tumor size), and bioinformatic analyses suggest involvement in cancer-related processes via a predicted circRNA-miRNA-mRNA network.
Confidence score:

0.6548
Other information
Title:

Circular RNA expression profile of lung squamous cell carcinoma: identification of potential biomarkers and therapeutic targets.

Journal: Bioscience reports
Published: 2020
PubMed ID: 32309852
Study type:

combined biological and clinical study
Data availability: -
Code availability: -