circRNA basic information
circBase ID: -
Name: hsa_circ_FoxO3
Synonym: -
Host Gene: FoxO3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006143
MONDO name: cervical squamous cell carcinoma
Disease details: squamous cervical cancer
Disease DO ID:
 3744
Disease MeSH ID:
 -
Disease NCIt ID:
 C4028
Disease ICD11 ID:
 1544785014
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Associated with aggressive behaviors of SCC (deeper stromal invasion and lymph node metastasis) and predicts prognosis (OS and RFS).
Molecular mechanism: Not explored in SCC in this study.
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; divergent primers PCR; Clinical Sample Validation; Cohort Study; Survival Analysis
Clinical significance:

Decreased serum circFoxO3a is associated with deeper stromal invasion, positive lymph node metastasis, and poorer OS/RFS; serum circFoxO3a is an independent unfavorable prognostic factor and a prognostic biomarker for SCC.
Description:

Serum circFoxO3a is down-regulated in squamous cervical cancer patients. Lower serum circFoxO3a correlates with aggressive clinicopathologic features and independently predicts worse OS and RFS, supporting its use as a noninvasive prognostic biomarker.
Confidence score:

0.6355
Other information
Title:

Serum Circular FoxO3a Serves as a Novel Prognostic Biomarker in Squamous Cervical Cancer.

Journal: Cancer management and research
Published: 2020
PubMed ID: 32308490
Study type:

clinical study
Data availability: The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.
Code availability: https://www.r-project.org/