| Expression pattern: |
DN |
| Associated gene: |
Yap mRNA, eIF4G, PABP, eIF4E, eIF4A, eIF4B |
| Associated microRNA: |
- |
| Biological function: |
suppresses proliferation, migration, invasion, adhesion and colony formation of cancer cells; antagonizes Yap protein expression by inhibiting translation |
| Molecular mechanism: |
circYap binds Yap mRNA and translation initiation factors (PABP, eIF4G) to competitively inhibit PABP-eIF4G interaction and suppress Yap translation initiation |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; divergent primers PCR; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; Colony Formation Assay; CCK8; Transwell Assay; Wound Healing Assay; Co-IP |
| Clinical significance: |
circYap levels were significantly lower in tumor tissues compared to adjacent breast tissues |
| Description: |
circYap (from YAP1) is down-regulated in breast cancer tissues and mainly localized in the cytoplasm. It binds Yap mRNA and the translation initiation factors PABP/eIF4G to disrupt their interaction, thereby suppressing YAP translation and inhibiting malignant phenotypes (proliferation, colony formation, migration/invasion). |
| Confidence score: |
0.8075 |