| Expression pattern: |
UP |
| Associated gene: |
DUSP7 |
| Associated microRNA: |
let-7a-5p |
| Biological function: |
promotes paclitaxel resistance, invasion and autophagy; inhibits apoptosis; promotes in vivo tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circ-ABCB10 sponges let-7a-5p to up-regulate DUSP7, thereby promoting PTX resistance and malignant phenotypes in PTX-resistant BC cells |
| Biological pathway or process: |
ceRNA regulation (promotes); apoptosis (inhibits); invasion (promotes); autophagy (promotes); chemoresistance (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; IF (Immunofluorescence); In Vivo Animal Model |
| Clinical significance: |
circ-ABCB10 is up-regulated in PTX-resistant BC tissues compared with PTX-sensitive tissues, suggesting association with PTX resistance. |
| Description: |
circ-ABCB10 is up-regulated in PTX-resistant breast cancer tissues/cells and promotes paclitaxel resistance. Functionally, its knockdown increases PTX sensitivity and apoptosis while reducing invasion and autophagy, and suppresses xenograft tumor growth. Mechanistically, circ-ABCB10 sponges let-7a-5p to relieve repression of DUSP7 (circ-ABCB10/let-7a-5p/DUSP7 ceRNA axis). |
| Confidence score: |
0.6542 |