circRNA basic information
circBase ID: hsa_circ_0000511
Name: hsa_circ_RPPH1
Synonym: Circular RNA 0000511
Host Gene: RPPH1
Genomic location(hg19): chr14:20811282-20811431:-
Genomic location(hg38): chr14:20343123-20343272:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissue specimens; adjacent non-tumor tissue specimens; tumor tissues
Cell lines:

MCF-7; SK-BR-3; MDA-MB-231; MDA-MB-468; MCF-10A
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TAZ
Associated microRNA: miR-326
Biological function: Promotes proliferation, migration and invasion, and inhibits apoptosis of breast cancer cells; promotes tumor growth in vivo.
Molecular mechanism: Acts as a miR-326 sponge to upregulate TAZ expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Transfection; Colony Formation Assay; MTT; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation
Clinical significance:

-
Description:

circ_0000511 is up-regulated in breast cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-326 to relieve repression of TAZ, thereby increasing TAZ expression and tumor growth in vivo.
Confidence score:

0.6971
Other information
Title:

Circ_0000511 accelerates the proliferation, migration and invasion, and restrains the apoptosis of breast cancer cells through the miR‑326/TAZ axis.

Journal: International journal of oncology
Published: 2021
PubMed ID: 33649821
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -