circRNA basic information
circBase ID: hsa_circ_0001588
Name: hsa_circ_HIST1H4E
Synonym: -
Host Gene: HIST1H4E
Genomic location(hg19): chr6:26204839-26205043:+
Genomic location(hg38): chr6:26204611-26204815:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung adenocarcinoma tissues; adjacent tissues; tumor tissues
Cell lines:

SPC-A-1; H1975; A549; H1299
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: NACC1, HIST1H4E
Associated microRNA: miR-524-3p
Biological function: Acts as an oncogene and promotes proliferation, migration, invasion, metastasis, and tumor growth of lung adenocarcinoma cells.
Molecular mechanism: hsa_circ_0001588 functions as a ceRNA that binds miR-524-3p and upregulates NACC1 expression, thereby promoting malignant progression of lung adenocarcinoma.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; EdU Staining; Transwell Assay; In Vivo Animal Model; Western Blot; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Elevated hsa_circ_0001588 expression was associated with tumor size, lymphatic metastasis, distant metastasis, shorter survival time, poor clinicopathological features, and adverse prognosis; hsa_circ_0001588 may be an underlying therapeutic target for lung adenocarcinoma.
Description:

hsa_circ_0001588 is upregulated in lung adenocarcinoma tissues and cell lines and high expression is associated with poor clinicopathological features and adverse prognosis. Functionally, it promotes proliferation, migration, invasion, metastasis, and in vivo tumor growth. Mechanistically, cytoplasmic hsa_circ_0001588 acts as a ceRNA for miR-524-3p to increase NACC1 expression, supporting its potential as a therapeutic target.
Confidence score:

0.8162
Other information
Title:

Circular RNA hsa_circ_0001588 promotes the malignant progression of lung adenocarcinoma by modulating miR-524-3p/NACC1 signaling.

Journal: Life sciences
Published: 2020
PubMed ID: 32735888
Study type:

combined biological and clinical study
Data availability: All data included in this study are available upon request by contacting the corresponding author.
Code availability: -