| Expression pattern: |
DN |
| Associated gene: |
RUS1, RSU1, PINCH1, ILK, E-cadherin, alpha-SMA |
| Associated microRNA: |
miR-421 |
| Biological function: |
Inhibits proliferation and invasion; induces apoptosis (tumor suppressor role) in ovarian cancer cells. |
| Molecular mechanism: |
Acts as a competitive sponge (ceRNA) for miR-421 to increase RSU1 expression (reported as RUS1/RSU1). |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (inhibits); invasion (inhibits); apoptosis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circEXOC6B is down-regulated in ovarian cancer cell lines (SKOV3 and OVCAR3 vs IOSE80) and acts as a tumor suppressor. It inhibits proliferation and invasion and promotes apoptosis by sponging miR-421, thereby relieving miR-421-mediated repression of RSU1. |
| Confidence score: |
0.5997 |