circRNA basic information
circBase ID: hsa_circ_0004826
Name: hsa_circ_UTRN
Synonym: -
Host Gene: UTRN
Genomic location(hg19): chr6:144808683-144814592:+
Genomic location(hg38): chr6:144487547-144493456:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bladder cancer tissues; adjacent noncancerous tissues
Cell lines:

EJ; 253J-BV; 5637; T24; SV-HUC-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-145, hsa-miR-1282, hsa-miR-326, hsa-miR-558, hsa-miR-330-5p
Biological function: inhibits proliferation; inhibits migration; inhibits invasion (tumor suppressor effect) in bladder cancer cells
Molecular mechanism: Predicted ceRNA network (circRNA-miRNA-mRNA); downstream miRNAs and proteins were not experimentally validated.
Biological pathway or process:

ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Clinical Sample Validation; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Transfection
Clinical significance:

Lower expression is associated with worse clinicopathological features; diagnostic value (ROC AUC 0.790); low expression correlates with shorter OS and RFS; independent prognostic factor.
Description:

hsa_circ_0004826 is significantly down-regulated in bladder cancer and functions as a tumor suppressor, as its overexpression inhibits proliferation, migration, and invasion of BC cells. Clinically, low expression is associated with aggressive features and poorer survival, and it shows diagnostic potential by ROC analysis. It is included in a bioinformatically predicted circRNA-miRNA-mRNA (ceRNA) network, but downstream targets were not validated experimentally.
Confidence score:

0.7617
Other information
Title:

Downregulated hsa_circ_0077837 and hsa_circ_0004826, facilitate bladder cancer progression and predict poor prognosis for bladder cancer patients.

Journal: Cancer medicine
Published: 2020
PubMed ID: 32250047
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during this study are available from the corresponding author on reasonable request.
Code availability: -