| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-432 |
| Biological function: |
Associated with advanced tumor features and poor survival; suggested oncogenic role in bladder cancer. |
| Molecular mechanism: |
Negative correlation with miR-432; predicted binding site analyzed by RNAhybrid (binding suggested but not functionally validated in this study). |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ-SMARCA5 expression correlates with larger tumor size, higher tumor stage, LYN metastasis, and shorter DFS and OS; it is an independent predictive factor for worse DFS and OS. |
| Description: |
In this retrospective cohort of bladder cancer patients, circ-SMARCA5 is up-regulated in tumor tissues and negatively correlated with miR-432. High circ-SMARCA5 expression associates with more aggressive clinicopathologic features and independently predicts shorter DFS and OS. |
| Confidence score: |
0.6023 |