| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-1236, hsa-miR-21, hsa-miR-1205, hsa-miR-7, hsa-miR-942 |
| Biological function: |
inhibits proliferation; inhibits migration; inhibits invasion (tumor suppressor effect) in bladder cancer cells |
| Molecular mechanism: |
Predicted ceRNA network (circRNA-miRNA-mRNA); downstream miRNAs and proteins were not experimentally validated. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Clinical Sample Validation; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Transfection |
| Clinical significance: |
Lower expression is associated with worse clinicopathological features; diagnostic value (ROC AUC 0.775); low expression correlates with shorter OS and RFS; independent prognostic factor. |
| Description: |
hsa_circ_0077837 is significantly down-regulated in bladder cancer and acts as a tumor suppressor by inhibiting proliferation, migration, and invasion in BC cells when overexpressed. Low expression is associated with adverse clinicopathological features and poorer OS/RFS, with diagnostic potential by ROC analysis. Mechanistically, it is analyzed within a predicted circRNA-miRNA-mRNA (ceRNA) network without downstream experimental validation. |
| Confidence score: |
0.7617 |