circRNA basic information
circBase ID: hsa_circ_0077837
Name: hsa_circ_EPB41L2
Synonym: -
Host Gene: EPB41L2
Genomic location(hg19): chr6:131247744-131277639:-
Genomic location(hg38): chr6:130926604-130956499:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
4007
Disease MeSH ID:
-
Disease NCIt ID:
C4912
Disease ICD11 ID:
-
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

bladder cancer tissues; adjacent noncancerous tissues

Cell lines:

EJ; 253J-BV; 5637; T24; SV-HUC-1

In vivo animal model:

-

circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-1236, hsa-miR-21, hsa-miR-1205, hsa-miR-7, hsa-miR-942
Biological function: inhibits proliferation; inhibits migration; inhibits invasion (tumor suppressor effect) in bladder cancer cells
Molecular mechanism: Predicted ceRNA network (circRNA-miRNA-mRNA); downstream miRNAs and proteins were not experimentally validated.
Biological pathway or process:

ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits)

Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Clinical Sample Validation; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Transfection

Clinical significance:

Lower expression is associated with worse clinicopathological features; diagnostic value (ROC AUC 0.775); low expression correlates with shorter OS and RFS; independent prognostic factor.

Description:

hsa_circ_0077837 is significantly down-regulated in bladder cancer and acts as a tumor suppressor by inhibiting proliferation, migration, and invasion in BC cells when overexpressed. Low expression is associated with adverse clinicopathological features and poorer OS/RFS, with diagnostic potential by ROC analysis. Mechanistically, it is analyzed within a predicted circRNA-miRNA-mRNA (ceRNA) network without downstream experimental validation.

Confidence score:

0.7617

Other information
Title:

Downregulated hsa_circ_0077837 and hsa_circ_0004826, facilitate bladder cancer progression and predict poor prognosis for bladder cancer patients.

Journal: Cancer medicine
Published: 2020
PubMed ID: 32250047
Study type:

combined biological and clinical study

Data availability: The datasets used and/or analyzed during this study are available from the corresponding author on reasonable request.
Code availability: -