| Expression pattern: |
UP |
| Associated gene: |
RAB14 |
| Associated microRNA: |
miR-338-3p |
| Biological function: |
promotes proliferation and migration; inhibits apoptosis; promotes tumor growth in vivo |
| Molecular mechanism: |
Acts as a miR-338-3p sponge to inhibit miR-338-3p activity, thereby upregulating RAB14 (posttranscriptional regulation). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; FISH / smFISH; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
High expression of hsa_circ_0000326 was correlated with tumor size, regional lymph node status and differentiation in human lung adenocarcinoma. |
| Description: |
hsa_circ_0000326 is up-regulated in lung adenocarcinoma and is associated with more aggressive clinicopathologic features. It promotes proliferation and migration and inhibits apoptosis by sponging miR-338-3p to increase RAB14 expression, and its knockdown suppresses xenograft tumor growth. |
| Confidence score: |
0.7421 |