circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
0011786
MONDO name: allergic rhinitis
Disease details: Allergic rhinitis
Disease DO ID:
4481
Disease MeSH ID:
-
Disease NCIt ID:
C79532
Disease ICD11 ID:
1711769234
Disease OMIM ID:
-
Species: Human
Species details: Homo sapiens
Tissue specimen:

nasal mucosa

Cell lines:

293T

In vivo animal model:

other disease animal model

circRNA-disease information
Expression pattern:
UP
Associated gene: LncGAS5, GATA-3
Associated microRNA: miR-495
Biological function: Promotes Th2 differentiation and aggravates allergic rhinitis symptoms; knockdown alleviates nasal inflammation and symptoms.
Molecular mechanism: Acts as a ceRNA by directly binding miR-495, downregulating miR-495 and thereby increasing GATA-3 expression.
Biological pathway or process:

immune regulation (promotes); ceRNA regulation (promotes)

Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; RNA Pull-Down; FISH / smFISH; In Vivo Animal Model; H&E Staining; ELISA; Western Blot; Flow Cytometry(Non-apoptosis/cycle)

Clinical significance:

Potential therapeutic target for treating AR; intranasal knockdown alleviates AR symptoms.

Description:

CircHIPK3 is up-regulated in AR nasal mucosa and promotes Th2 differentiation and AR inflammation. Mechanistically, it binds and suppresses miR-495, relieving repression on GATA-3 and increasing GATA-3 expression; intranasal knockdown reduces AR symptoms in mice.

Confidence score:

0.7094

Other information
Title:

The regulatory network among CircHIPK3, LncGAS5, and miR-495 promotes Th2 differentiation in allergic rhinitis.

Journal: Cell death & disease
Published: 2020
PubMed ID: 32242002
Study type:

combined biological and clinical study

Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -