| Expression pattern: |
UP |
| Associated gene: |
LncGAS5, GATA-3 |
| Associated microRNA: |
miR-495 |
| Biological function: |
Promotes Th2 differentiation and aggravates allergic rhinitis symptoms; knockdown alleviates nasal inflammation and symptoms. |
| Molecular mechanism: |
Acts as a ceRNA by directly binding miR-495, downregulating miR-495 and thereby increasing GATA-3 expression. |
| Biological pathway or process: |
immune regulation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Luciferase Reporter Assay; RNA Pull-Down; FISH / smFISH; In Vivo Animal Model; H&E Staining; ELISA; Western Blot; Flow Cytometry（Non-apoptosis/cycle） |
| Clinical significance: |
Potential therapeutic target for treating AR; intranasal knockdown alleviates AR symptoms. |
| Description: |
CircHIPK3 is up-regulated in AR nasal mucosa and promotes Th2 differentiation and AR inflammation. Mechanistically, it binds and suppresses miR-495, relieving repression on GATA-3 and increasing GATA-3 expression; intranasal knockdown reduces AR symptoms in mice. |
| Confidence score: |
0.7094 |