circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; contiguous noncancerous tissue samples; xenograft tumors
Cell lines:

GES-1; HGC-27; AGS
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PIK3R1
Associated microRNA: miR-876-5p
Biological function: promotes proliferation, migration, invasion, glutaminolysis and tumor growth in gastric cancer
Molecular mechanism: ceRNA mechanism: circHIPK3 sponges miR-876-5p to increase PIK3R1
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); glutaminolysis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Clinical Sample Validation; Transfection; MTT; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model
Clinical significance:

-
Description:

CircHIPK3 is up-regulated in gastric cancer tissues and cell lines and promotes proliferation, migration, invasion, glutaminolysis, and xenograft tumor growth. Mechanistically, it acts as a ceRNA to sponge miR-876-5p and thereby increases PIK3R1 expression.
Confidence score:

0.7164
Other information
Title:

CircHIPK3/miR-876-5p/PIK3R1 axis regulates regulation proliferation, migration, invasion, and glutaminolysis in gastric cancer cells.

Journal: Cancer cell international
Published: 2020
PubMed ID: 32817745
Study type:

combined biological and clinical study
Data availability: All data generated or analysed during this study are included in this published article.
Code availability: -