| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
inhibits proliferation; inhibits invasion; inhibits migration |
| Molecular mechanism: |
Protein-coding circRNA: circFNDC3B encodes circFNDC3B-218aa; the inhibitory phenotypes in CC are mainly attributed to circFNDC3B-218aa rather than the circular RNA form. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; FISH / smFISH; Clinical Sample Validation; Cohort Study; Survival Analysis; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay |
| Clinical significance: |
Patients with lower circFNDC3B expression had a significantly shorter OS than patients with higher expression; circFNDC3B expression was an independent prognostic factor for CC prognosis. |
| Description: |
circFNDC3B is down-regulated in colon cancer tissues and cell lines and functions as a tumor suppressor by inhibiting proliferation, invasion, and migration. Low circFNDC3B expression is associated with shorter overall survival, indicating prognostic relevance. |
| Confidence score: |
0.7996 |