| Expression pattern: |
UP |
| Associated gene: |
MAPK1 |
| Associated microRNA: |
miR-217 |
| Biological function: |
promotes HCC cell proliferation (and invasion) in vitro |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: circMAN2B2 sponges miR-217, relieving miR-217-mediated repression of MAPK1, thereby increasing MAPK1 expression and promoting proliferation |
| Biological pathway or process: |
proliferation (promotes); MAPK (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining |
| Clinical significance: |
circMAN2B2 expression was closely related to the prognosis of HCC patients; up-regulation positively correlated with TNM stage |
| Description: |
circMAN2B2 is up-regulated in HCC tissues and promotes HCC cell proliferation. Mechanistically, it functions as a ceRNA that sponges miR-217, thereby increasing MAPK1 expression; MAPK1 overexpression rescues the proliferation inhibition caused by circMAN2B2 knockdown. |
| Confidence score: |
0.6369 |