| Expression pattern: |
UP |
| Associated gene: |
c-Myc, TGF-beta, p-SMAD2, SMAD2, MMP9, E-cadherin, N-cadherin, Vimentin, Slug |
| Associated microRNA: |
miR-33b, miR-93 |
| Biological function: |
Promotes gastric cancer growth, proliferation, migration and invasion; inhibits apoptosis; promotes tumorigenesis and metastasis; induces EMT. |
| Molecular mechanism: |
Activates c-Myc and TGF-beta/SMAD signaling; regulates EMT marker expression; (discussion cites a miRNA-sponge relationship with miR-33b and miR-93 to upregulate c-Myc). |
| Biological pathway or process: |
TGF-beta/SMAD (promotes); EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
Upregulation in GC tissues was associated with tumor stage and lymphatic metastasis; suggested as a potential biomarker for GC. |
| Description: |
circCCDC66 is up-regulated in gastric cancer tissues and cell lines and is associated with higher tumor stage and lymphatic metastasis. Functionally, it promotes GC cell proliferation, migration, invasion and tumor growth while inhibiting apoptosis. Mechanistically, it activates c-Myc and TGF-beta/SMAD signaling and promotes EMT. |
| Confidence score: |
0.622 |