circRNA basic information
circBase ID: hsa_circ_0000977
Name: hsa_circ_NOL10
Synonym: hsa_circRNA_102619
Host Gene: NOL10
Genomic location(hg19): chr2:10784445-10808849:-
Genomic location(hg38): chr2:10644319-10668723:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; matched normal tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: FOXO1, MBNL1, MEF2C, RECK, PPM1E, TTLL7, PCP4L1
Associated microRNA: miR-135b-5p, miR-4766-3p, miR-374a-3p
Biological function: -
Molecular mechanism: Potential ceRNA mechanism via the hsa_circ_0000977/miR-135b-5p axis, positively correlated with downstream targets (FOXO1, MBNL1, MEF2C, RECK, PPM1E, TTLL7, PCP4L1) in CRC.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0000977 is down-regulated in colorectal cancer tissues and is proposed to act in a ceRNA network, with a key statistically significant axis hsa_circ_0000977/miR-135b-5p. The study connects this axis to positively correlated downstream targets (FOXO1, MBNL1, MEF2C, RECK, PPM1E, TTLL7, PCP4L1) based on in silico analyses and RT-qPCR validation in clinical samples.
Confidence score:

0.4032
Other information
Title:

Whole-transcriptome analysis reveals a potential hsa_circ_0001955/hsa_circ_0000977-mediated miRNA-mRNA regulatory sub-network in colorectal cancer.

Journal: Aging
Published: 2020
PubMed ID: 32221048
Study type:

combined biological and clinical study
Data availability: GSE126095; GSE126094; GSE126093; GSE126092
Code availability: -