circRNA basic information
circBase ID: hsa_circ_0001955
Name: hsa_circ_CSNK1G1
Synonym: hsa_circRNA_101555
Host Gene: CSNK1G1
Genomic location(hg19): chr15:64495280-64508912:-
Genomic location(hg38): chr15:64203081-64216713:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; matched normal tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CDK6, MMP12, RAB3IP
Associated microRNA: miR-145-5p
Biological function: -
Molecular mechanism: Potential ceRNA mechanism via the hsa_circ_0001955/miR-145-5p axis, positively correlated with downstream targets (CDK6, MMP12, RAB3IP) in CRC.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0001955 is up-regulated in colorectal cancer tissues and is proposed to function as a ceRNA by sponging miR-145-5p. The study links this axis to positively correlated downstream targets (CDK6, MMP12, RAB3IP) based on in silico network analyses and RT-qPCR validation in clinical samples.
Confidence score:

0.4032
Other information
Title:

Whole-transcriptome analysis reveals a potential hsa_circ_0001955/hsa_circ_0000977-mediated miRNA-mRNA regulatory sub-network in colorectal cancer.

Journal: Aging
Published: 2020
PubMed ID: 32221048
Study type:

combined biological and clinical study
Data availability: GSE126095; GSE126094; GSE126093; GSE126092
Code availability: -