| Expression pattern: |
UP |
| Associated gene: |
GPRC5A, PCNA, Vimentin, E-cadherin, Ki67 |
| Associated microRNA: |
miR-5195-3p |
| Biological function: |
circ_0007351 exerts an oncogenic role in colorectal cancer; circ_0007351 down-regulation impedes colorectal cancer cell proliferation, colony formation, motility, invasion and xenograft tumor growth. |
| Molecular mechanism: |
circ_0007351 acts as a miR-5195-3p sponge and positively regulates GPRC5A expression through miR-5195-3p competition, forming the circ_0007351/miR-5195-3p/GPRC5A cascade. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; EdU Staining; Colony Formation Assay; Transwell Assay; Western Blot; RNA Pull-Down; Luciferase Reporter Assay; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_0007351 inhibition may have a potential therapeutic value for colorectal cancer. |
| Description: |
circ_0007351 is a human AGTPBP1-derived circRNA that is up-regulated in colorectal cancer tissues and cell lines. It promotes colorectal cancer cell proliferation, motility, invasion and xenograft tumor growth by sponging miR-5195-3p and thereby increasing GPRC5A expression. The study suggests that inhibiting circ_0007351 may have therapeutic potential for colorectal cancer. |
| Confidence score: |
0.7552 |