| Expression pattern: |
UP |
| Associated gene: |
TGFBR1 |
| Associated microRNA: |
miR-331-3p |
| Biological function: |
promotes gastric cancer progression by enhancing proliferation (context-dependent), migration, invasion, EMT, and in vivo tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circCACTIN sponges miR-331-3p to increase TGFBR1 mRNA/protein expression |
| Biological pathway or process: |
ceRNA regulation (promotes); EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); TGF-beta/SMAD (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
CircCACTIN could be a novel biomarker and therapeutic target for GC patients. |
| Description: |
circCACTIN (hsa_circ_0092303) is up-regulated in gastric cancer tissues and cell lines and promotes malignant phenotypes (migration/invasion, EMT, and xenograft tumor growth). It acts as a ceRNA by sponging miR-331-3p, thereby increasing TGFBR1 expression and engaging the TGF-beta/EMT program. |
| Confidence score: |
0.7855 |