circRNA basic information
circBase ID: hsa_circ_0008792
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr9:118969734-119033695:+
Genomic location(hg38): chr9:116207455-116271416:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MG63; U2OS; hFOB1.19; HEK293
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: ZFP1
Associated microRNA: hsa-miR-711
Biological function: inhibits migration and invasion; promotes apoptosis; suppresses proliferation
Molecular mechanism: ceRNA/miRNA sponge: hsa_circ_0008792 sponges hsa-miR-711 to up-regulate ZFP1
Biological pathway or process:

migration (inhibits); invasion (inhibits); apoptosis (promotes); proliferation (inhibits); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Transfection; Luciferase Reporter Assay; Wound Healing Assay; Transwell Assay; CCK8; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Western Blot
Clinical significance:

-
Description:

hsa_circ_0008792 is down-regulated in osteosarcoma cell lines. Its up-regulation suppresses migration, invasion, and proliferation and promotes apoptosis by sponging hsa-miR-711 to increase ZFP1 expression, forming the hsa_circ_0008792/hsa-miR-711/ZFP1 axis.
Confidence score:

0.6004
Other information
Title:

Up-Regulation of Hsa_circ_0008792 Inhibits Osteosarcoma Cell Invasion and Migration and Promotes Apoptosis by Regulating Hsa-miR-711/ZFP1.

Journal: OncoTargets and therapy
Published: 2020
PubMed ID: 32210583
Study type:

combined biological and clinical study
Data availability: GSE96962
Code availability: -